Thromboembolism

Venous thromboembolism prophylaxis in adults with acute traumatic brain injury: A systematic review.

Citation
Forte ML, Brandt S, Claussen AM, Tignanelli CJ, Shah S, Butler M. Venous thromboembolism prophylaxis in adults with acute traumatic brain injury: A systematic review. Trauma Surg Acute Care Open. 2025 Jun 22;10(2):e001691. doi: 10.1136/tsaco-2024-001691. PMID: 40552210; PMCID: PMC12184397.
Principal Investigator
Tignanelli, Christopher J.
Melton-Meaux, Genevieve
Project Name
Evaluation of the SCALED (SCaling AcceptabLE cDs) Approach for the Implementation of Interoperable Clinical Decision Support for Venous Thromboembolism Prevention

Impact of a clinical decision support system on CT pulmonary angiography yield and utilization in hospitalized patients.

Citation
Sharma A, Isabelle M, Hunsaker A, Dutta S, Lucier D, Rosovsky RP, Saini S, Landman A, Raja AS, Khorasani R, Lacson R. Impact of a clinical decision support system on CT pulmonary angiography yield and utilization in hospitalized patients. J Am Coll Radiol. 2025 Apr;22(4):449-460. doi: 10.1016/j.jacr.2024.11.030. Epub 2024 Dec 9. PMID: 39662713.
Principal Investigator
Lacson, Ronilda
Project Name
Clinical Decision Support for Disseminating and Implementing Patient-Centered Outcomes Research Clinical Evidence

Complexity, Incidence, and Costs Related to Delayed Diagnosis of Venous Thromboembolism in Urban and Rural Primary and Urgent Care Settings

Description

This research aims to improve the early detection of venous thromboembolism in primary and urgent care by using mixed methods (stakeholder interviews and surveys, electronic health records, and machine learning) to better understand missed and delayed diagnoses, identify risk factors, and develop tools to enhance patient safety.

Grant Number
R01 HS030221
Principal Investigator(s)
Dykes, Patricia
Chen, Jin

Universal clinical decision support tool for thromboprophylaxis in hospitalized COVID-19 patients: Post hoc analysis of the IMPROVE-DD cluster randomized trial.

Citation
Goldin M, Tsaftaridis N, Koulas I, Solomon J, Qiu M, Leung T, Smith K, Ochani K, McGinn T, Spyropoulos AC. Universal clinical decision support tool for thromboprophylaxis in hospitalized COVID-19 patients: Post hoc analysis of the IMPROVE-DD cluster randomized trial. J Thromb Haemost. 2024 Nov;22(11):3172-3182. doi: 10.1016/j.jtha.2024.07.025. Epub 2024 Aug 14. PMID: 39128654.
Principal Investigator
Spyropoulos, Alex
McGinn, Thomas G.
Project Name
Implementation of a Novel Multi-Platform Evidence-Based Clinical Decision Support System

A pragmatic, stepped-wedge, hybrid type II trial of interoperable clinical decision support to improve venous thromboembolism prophylaxis for patients with traumatic brain injury.

Citation
Tignanelli CJ, Shah S, Vock D, Siegel L, Serrano C, Haut E, Switzer S, Martin CL, Rizvi R, Peta V, Jenkins PC, Lemke N, Thyvalikakath T, Osheroff JA, Torres D, Vawdrey D, Callcut RA, Butler M, Melton GB. A pragmatic, stepped-wedge, hybrid type II trial of interoperable clinical decision support to improve venous thromboembolism prophylaxis for patients with traumatic brain injury. Implement Sci. 2024 Aug 5;19(1):57. doi: 10.1186/s13012-024-01386-4. PMID: 39103955; PMCID: PMC11299263.
Principal Investigator
Tignanelli, Christopher J.
Melton-Meaux, Genevieve
Project Name
Evaluation of the SCALED (SCaling AcceptabLE cDs) Approach for the Implementation of Interoperable Clinical Decision Support for Venous Thromboembolism Prevention

Integrating clinical decision support into electronic health record systems using a novel platform (EvidencePoint): Developmental study.

Citation
Solomon J, Dauber-Decker K, Richardson S, Levy S, Khan S, Coleman B, Persaud R, Chelico J, King D, Spyropoulos A, McGinn T. Integrating clinical decision support into electronic health record systems using a novel platform (EvidencePoint): Developmental study. JMIR Form Res. 2023 Oct 19;7:e44065. doi: 10.2196/44065. PMID: 37856193; PMCID: PMC10623239.
Principal Investigator
Spyropoulos, Alex
McGinn, Thomas G.
Project Name
Implementation of a Novel Multi-Platform Evidence-Based Clinical Decision Support System

Universal EHRs clinical decision support for thromboprophylaxis in medical inpatients: A cluster randomized trial.

Citation
Spyropoulos AC, Goldin M, Koulas I, Solomon J, Qiu M, et al. Universal EHRs clinical decision support for thromboprophylaxis in medical inpatients: A cluster randomized trial. JACC: Advances, Volume 2, Issue 8,
2023,100597, ISSN 2772-963X, https://doi.org/10.1016/j.jacadv.2023.100597.
Principal Investigator
Spyropoulos, Alex
McGinn, Thomas G.
Project Name
Implementation of a Novel Multi-Platform Evidence-Based Clinical Decision Support System

Clinical Decision Support for Disseminating and Implementing Patient-Centered Outcomes Research Clinical Evidence

Description

This research will create clinical decision support artifacts for three patient-centered outcomes research guidelines around advanced diagnostic imaging using standards to allow them to be shareable, interoperable, and scalable; and implement them in different workflows and settings measuring their impact. 

Grant Number
R18 HS028616
Principal Investigator(s)
Lacson, Ronilda

Drug-drug interaction between dexamethasone and direct-acting oral anticoagulants: A nested case-control study in the national COVID cohort collaborative (N3C).

Citation
Kravchenko OV, Boyce RD, Gomez-Lumbreras A, Kocis PT, Villa Zapata L, Tan M, Leonard CE, Andersen KM, Mehta H, Alexander GC, Malone DC; N3C consortium. Drug-drug interaction between dexamethasone and direct-acting oral anticoagulants: A nested case-control study in the national COVID cohort collaborative (N3C). BMJ Open. 2022 Dec 29;12(12):e066846. doi: 10.1136/bmjopen-2022-066846. PMID: 36581417; PMCID: PMC9806069.
Principal Investigator
Malone, Daniel C.
Project Name
Meaningful Drug Interaction Alerts