Patient

A novel application of SMART on FHIR architecture for interoperable and scalable integration of patient-reported outcome data with electronic health records.

Citation
Wesley DB, Blumenthal J, Shah S, Littlejohn RA, Pruitt Z, Dixit R, Hsiao CJ, Dymek C, Ratwani RM. A novel application of SMART on FHIR architecture for interoperable and scalable integration of patient-reported outcome data with electronic health records. J Am Med Inform Assoc. 2021 Sep 18;28(10):2220-2225. doi: 10.1093/jamia/ocab110. PMID: 34279660; PMCID: PMC8449622.
Principal Investigator
Wesley, Deliya
Ratwani, Raj M.
Project Name
Advancing the Collection and Use of Patient-Reported Outcomes Through Health Information Technology

Comparing the performance of screening surveys versus predictive models in identifying patients in need of health-related social need services in the emergency department.

Citation
Mazurenko O, Hirsh AT, Harle CA, Shen J, McNamee C, Vest JR. Comparing the performance of screening surveys versus predictive models in identifying patients in need of health-related social need services in the emergency department. PLoS One. 2024 Nov 20;19(11):e0312193. doi: 10.1371/journal.pone.0312193. PMID: 39565746; PMCID: PMC11578524.
Principal Investigator
Vest, Joshua Ryan
Project Name
Predictive Modeling for Social Needs in Emergency Department Settings

Integrating a risk prediction score in a clinical decision support to identify patients with health-related social needs in the emergency department.

Citation
Mazurenko O, Harle CA, Musey PI Jr, Schleyer TK, Sanner LM, Vest JR. Integrating a risk prediction score in a clinical decision support to identify patients with health-related social needs in the emergency department. JAMIA Open. 2025 Jul 4;8(4):ooaf060. doi: 10.1093/jamiaopen/ooaf060. PMID: 40626324; PMCID: PMC12233013.
Principal Investigator
Vest, Joshua Ryan
Project Name
Predictive Modeling for Social Needs in Emergency Department Settings

Secondary analysis of Fluids and Catheters Treatment Trial (FACTT) data reveal poor clinical outcomes in acute respiratory distress syndrome patients with diabetes.

Citation
Alanazi AH, Almuntashiri S, Sikora A, Zhang D, Somanath PR. Secondary analysis of Fluids and Catheters Treatment Trial (FACTT) data reveal poor clinical outcomes in acute respiratory distress syndrome patients with diabetes. Respir Med. 2024 Mar;223:107540. doi: 10.1016/j.rmed.2024.107540. Epub 2024 Jan 28. PMID: 38290602; PMCID: PMC10985622.
Principal Investigator
Sikora, Andrea
Project Name
Machine Learning Validation of Medication Regimen Complexity for Critical Care Pharmacist Resource Prediction

Testing and masking policies and hospital-onset respiratory viral infections.

Citation
Pak TR, Chen T, Kanjilal S, McKenna CS, Rhee C, Klompas M. Testing and masking policies and hospital-onset respiratory viral infections. JAMA Netw Open. 2024 Nov 4;7(11):e2448063. doi: 10.1001/jamanetworkopen.2024.48063. PMID: 39602124; PMCID: PMC12549082.
Principal Investigator
Pak, Theodore R.
Project Name
Identifying Sepsis Phenotypes Associated with Antibiotic-Resistant Pathogens Using Large Language Models and Machine Learning

Does single dose epinephrine improve outcomes for patients with out-of-hospital cardiac arrest and bystander CPR or a shockable rhythm?

Citation
George TS, Ashburn NP, Snavely AC, Beaver BP, Chado MA, Cannon H, Costa CG, Winslow JE, Nelson RD, Stopyra JP, Mahler SA. Does single dose epinephrine improve outcomes for patients with out-of-hospital cardiac arrest and bystander CPR or a shockable rhythm? Prehosp Emerg Care. 2025;29(1):37-45. doi: 10.1080/10903127.2024.2348663. Epub 2024 May 21. PMID: 38713769; PMCID: PMC11579245.
Principal Investigator
Mahler, Simon A
Manning, John D.
Project Name
Digital EMS Point-of-Care Innovation to Improve Rural STEMI Outcomes

Collaborative development of a rules-based electronic health record algorithm for hospital-at-home eligibility.

Citation
Liu TL, Hetherington TC, Kowalkowski M, Knight ME, Culpepper J, McWilliams A, Chou SH, Isreal M, Murphy S. Collaborative development of a rules-based electronic health record algorithm for hospital-at-home eligibility. J Hosp Med. 2025 Oct;20(10):1140-1144. doi: 10.1002/jhm.70107. Epub 2025 Jun 29. PMID: 40583036.
Principal Investigator
Kowalkowski, Marc
McWilliams, Andrew D.
Project Name
Personalized Clinical Decision Support to Improve Participation in Hospital at Home

Area deprivation and patient complexity predict low-value healthcare utilization in persons with heart failure.

Citation
Ledwin KM, Casucci S, Sullivan SS, Hewner S. Area deprivation and patient complexity predict low-value healthcare utilization in persons with heart failure. Nurs Res. 2025 Mar-Apr 01;74(2):136-143. doi: 10.1097/NNR.0000000000000794. Epub 2024 Nov 15. PMID: 39616433; PMCID: PMC12510342.
Principal Investigator
Hewner, Sharon
Project Name
Implementing Personalized Cross-Sector Transitional Care Management to Promote Care Continuity, Reduce Low-Value Utilization, and Reduce the Burden of Treatment for High-Need, High-Cost Patients

Prebiotics as an adjunct therapy for posttraumatic stress disorder: A pilot randomized controlled trial.

Citation
Voigt RM, Engen PA, Villanueva M, Bambi SA, Green SJ, Naqib A, Raeisi S, Shaikh M, Hamaker BR, Cantu-Jungles TM, Pridgen SA, Held P, Keshavarzian A. Prebiotics as an adjunct therapy for posttraumatic stress disorder: A pilot randomized controlled trial. Front Neurosci. 2025 Jan 7;18:1477519. doi: 10.3389/fnins.2024.1477519. PMID: 39840022; PMCID: PMC11747240.
Principal Investigator
Held, Philip
Thompson, Hale M.
Project Name
A Machine Learning Health System to Integrate Care for Substance Misuse and HIV Treatment and Prevention Among Hospitalized Patients

Veterans' 12-month PTSD and depression outcomes following 2- and 3-week intensive cognitive processing therapy-based treatment.

Citation
Held P, Smith LJ, Parmar AM, Pridgen SA, Smith DL, Klassen B. Veterans' 12-month PTSD and depression outcomes following 2- and 3-week intensive cognitive processing therapy-based treatment. Eur J Psychotraumatol. 2024;15(1):2350908. doi: 10.1080/20008066.2024.2350908. Epub 2024 May 21. PMID: 38770596; PMCID: PMC11110869.
Principal Investigator
Held, Philip
Thompson, Hale M.
Project Name
A Machine Learning Health System to Integrate Care for Substance Misuse and HIV Treatment and Prevention Among Hospitalized Patients