Pak, Theodore R.

Association between the sequence of β-Lactam and vancomycin administration and mortality in patients with suspected sepsis.

Citation
Kondo Y, Klompas M, McKenna CS, Pak TR, Shappell CN, DelloStritto L, Rhee C. Association between the sequence of β-Lactam and vancomycin administration and mortality in patients with suspected sepsis. Clin Infect Dis. 2025 Apr 30;80(4):761-769. doi: 10.1093/cid/ciae599. PMID: 39657016; PMCID: PMC12043061.
Principal Investigator
Pak, Theodore R.
Project Name
Identifying Sepsis Phenotypes Associated with Antibiotic-Resistant Pathogens Using Large Language Models and Machine Learning

Identifying Sepsis Phenotypes Associated with Antibiotic-Resistant Pathogens Using Large Language Models and Machine Learning

Description

This research uses large language models and machine learning to retrospectively analyze electronic health records of patients with suspected sepsis and identify patterns in treatment outcomes, with the goal of shaping future clinical guidelines that help doctors select the most effective antibiotics for each patient, reduce unnecessary use of broad-spectrum antibiotics, lower the risks of drug resistance, and ultimately improve patient outcomes.

Grant Number
K08 HS030118
Principal Investigator(s)
Pak, Theodore R.