Case Study

Large language models management of complex medication regimens: A case-based evaluation.

Citation
Chase A, Most A, Xu S, Barreto E, Murray B, Henry K, Smith S, Hedrick T, Chen X, Li S, Liu T, Sikora A. Large language models management of complex medication regimens: A case-based evaluation. Front Pharmacol. 2025 Nov 24;16:1514445. doi: 10.3389/fphar.2025.1514445. PMID: 41368579; PMCID: PMC12682882.
Principal Investigator
Sikora, Andrea
Project Name
Artificial Intelligence-Based Health Information Technology Tools to Optimize Critical Care Pharmacist Resources Through Adverse Drug Event Prediction

Large language models management of complex medication regimens: A case-based evaluation.

Citation
Chase A, Most A, Xu S, Barreto E, Murray B, Henry K, Smith S, Hedrick T, Chen X, Li S, Liu T, Sikora A. Large language models management of complex medication regimens: A case-based evaluation. Front Pharmacol. 2025 Nov 24;16:1514445. doi: 10.3389/fphar.2025.1514445. PMID: 41368579; PMCID: PMC12682882.
Principal Investigator
Sikora, Andrea
Project Name
Machine Learning Validation of Medication Regimen Complexity for Critical Care Pharmacist Resource Prediction

Evaluating treatment burden in patients with complex needs receiving a transition of care intervention: A rapid qualitative analysis.

Citation
Bowen E, Ali N, Anderson AJ, Krolikowski A, Hewner S. Evaluating treatment burden in patients with complex needs receiving a transition of care intervention: A rapid qualitative analysis. Clin Nurs Res. 2025 Sep 28:10547738251378678. doi: 10.1177/10547738251378678. Epub ahead of print. PMID: 41015909.
Principal Investigator
Hewner, Sharon
Project Name
Implementing Personalized Cross-Sector Transitional Care Management to Promote Care Continuity, Reduce Low-Value Utilization, and Reduce the Burden of Treatment for High-Need, High-Cost Patients

Managing health without stable housing: Dimensions of treatment burden and patient capacity for people with chronic health conditions experiencing homelessness.

Citation
Bowen E, Anderson AJ, Capozziello N, Hewner S. Managing health without stable housing: Dimensions of treatment burden and patient capacity for people with chronic health conditions experiencing homelessness. Qual Health Res. 2025 Nov;35(13):1450-1463. doi: 10.1177/10497323241302673. Epub 2024 Dec 15. PMID: 39676283.
Principal Investigator
Hewner, Sharon
Project Name
Implementing Personalized Cross-Sector Transitional Care Management to Promote Care Continuity, Reduce Low-Value Utilization, and Reduce the Burden of Treatment for High-Need, High-Cost Patients

Evolution of clinical Health Information Exchanges to population health resources: A case study of the Indiana network for patient care.

Citation
Williams KS, Rahurkar S, Grannis SJ, Schleyer TK, Dixon BE. Evolution of clinical Health Information Exchanges to population health resources: A case study of the Indiana network for patient care. BMC Med Inform Decis Mak. 2025 Feb 24;25(1):97. doi: 10.1186/s12911-025-02933-9. PMID: 39994604; PMCID: PMC11849299.
Principal Investigator
Dixon, Brian
Project Name
Exploring the Utilization of and Outcomes from Health Information Exchange in Emergency Settings

Facilitators and barriers to integrating patient-generated blood pressure data into primary care EHR workflows.

Citation
Canfield SM, Koopman RJ. Facilitators and barriers to integrating patient-generated blood pressure data into primary care EHR workflows. Appl Clin Inform. 2024 Oct;15(5):942-951. doi: 10.1055/s-0044-1790554. Epub 2024 Nov 13. PMID: 39537189; PMCID: PMC11560398.
Principal Investigator
Koopman, Richelle J.
Project Name
Optimizing Display of Blood Pressure Data To Support Clinical Decision Making

A case study on language barriers, health literacy, and family interpretation: What is ethical communication?

Citation
Beaman LR, Barwise AK. A case study on language barriers, health literacy, and family interpretation: What is ethical communication? J Hosp Med. 2024 Sep 26. doi: 10.1002/jhm.13512. Epub ahead of print. PMID: 39327820.
Principal Investigator
Barwise, Amelia K.
Project Name
Harnessing Health Information Technology to Promote Equitable Care for Patients with Limited English Proficiency and Complex Care Needs

Is the promise of PROMs being realized? Implementation experience in a large orthopedic practice.

Citation
Ziegenfuss JY, Grossman ES, Solberg LI, Chrenka EA, Werner A, Asche SE, Norton CK, Nelson A, Reams M, Whitebird RR. Is the promise of PROMs being realized? Implementation experience in a large orthopedic practice. Am J Med Qual. 2022 Nov-Dec 01;37(6):489-494. doi: 10.1097/JMQ.0000000000000079. Epub 2022 Oct 31. PMID: 36314931.
Principal Investigator
Solberg, Leif
Project Name
Optimizing the Value of Patient-Reported Outcome Measures in Improving Care Delivery through Health Information Technology

Establishing a multidisciplinary initiative for interoperable electronic health record innovations at an academic medical center.

Citation
Kawamoto K, Kukhareva PV, Weir C, Flynn MC, Nanjo CJ, Martin DK, Warner PB, Shields DE, Rodriguez-Loya S, Bradshaw RL, Cornia RC, Reese TJ, Kramer HS, Taft T, Curran RL, Morgan KL, Borbolla D, Hightower M, Turnbull WJ, Strong MB, Chapman WW, Gregory T, Stipelman CH, Shakib JH, Hess R, Boltax JP, Habboushe JP, Sakaguchi F, Turner KM, Narus SP, Tarumi S, Takeuchi W, Ban H, Wetter DW, Lam C, Caverly TJ, Fagerlin A, Norlin C, Malone DC, Kaphingst KA, Kohlmann WK, Brooke BS, Del Fiol G. Establishing a multidisciplinary initiative for interoperable electronic health record innovations at an academic medical center. JAMIA Open. 2021 Jul 31;4(3):ooab041. doi: 10.1093/jamiaopen/ooab041. PMID: 34345802; PMCID: PMC8325485.
Principal Investigator
Kawamoto, Kensaku
Project Name
Scalable Decision Support and Shared Decision Making for Lung Cancer Screening

Evaluation in life cycle of information technology (ELICIT) framework: Supporting the innovation life cycle from business case assessment to summative evaluation.

Citation
Kukhareva PV, Weir C, Del Fiol G, Aarons GA, Taft TY, Schlechter CR, Reese TJ, Curran RL, Nanjo C, Borbolla D, Staes CJ, Morgan KL, Kramer HS, Stipelman CH, Shakib JH, Flynn MC, Kawamoto K. Evaluation in life cycle of information technology (ELICIT) framework: Supporting the innovation life cycle from business case assessment to summative evaluation. J Biomed Inform. 2022 Mar;127:104014. doi: 10.1016/j.jbi.2022.104014. Epub 2022 Feb 12. PMID: 35167977; PMCID: PMC8959015.
Principal Investigator
Kawamoto, Kensaku
Project Name
Scalable Decision Support and Shared Decision Making for Lung Cancer Screening