Randomized Controlled Trial (RCT)

A randomized controlled trial of artificial intelligence-based analytics for clinical deterioration.

Citation
Keim-Malpass J, Ratcliffe SJ, Clark MT, Krahn KN, Monfredi OJ, Hamil S, Yousefvand G, Jones MK, Nelson A, Moorman LP, Moorman JR, Bourque JM. A randomized controlled trial of artificial intelligence-based analytics for clinical deterioration. Sci Rep. 2026 Feb 5;16(1):7345. doi: 10.1038/s41598-026-39051-z. PMID: 41644641; PMCID: PMC12923516.
Principal Investigator
Keim-Malpass, Jessica
Bourque, Jamieson MacDonald
Project Name
Predictive Monitoring: IMPact of Real-Time Predictive Monitoring in Acute Care Cardiology Trial (PM-IMPACCT)

Virtual mentored implementation to improve care transitions in chronic obstructive pulmonary disease: Protocol for a pragmatic implementation study.

Citation
Lee CT, Traeger L, Akula M, Fegley AE, Goldstein J, Erwin K, Damschroder LJ, Rommes J, Pick H, Auerbach A, Lindenauer P, Wan W, Jackson Sagredo A, Press VG. Virtual mentored implementation to improve care transitions in chronic obstructive pulmonary disease: Protocol for a pragmatic implementation study. JMIR Res Protoc. 2026 Jan 13;15:e82043. doi: 10.2196/82043. PMID: 41529255; PMCID: PMC12848486.
Principal Investigator
Press, Valerie G.
Abraham, Joanna
Arora, Vineet
Project Name
TELE-TOC Telehealth Education Leveraging Electronic Transitions of Care for COPD Patients

Evaluating cost savings associated with a patient-facing asthma mobile health intervention.

Citation
Nadelmann J, Patel M, Lane S, Hammock J, Stark A, Jariwala SP. Evaluating cost savings associated with a patient-facing asthma mobile health intervention. Appl Clin Inform. 2025 Aug;16(4):1086-1094. doi: 10.1055/a-2595-3329. Epub 2025 Apr 28. PMID: 40294633; PMCID: PMC12431811.
Principal Investigator
Feldman, Jonathan M
Jariwala, Sunit
Project Name
A Novel Patient-Facing Mobile Platform to Collect and Implement Patient-Reported Outcomes and Voice Biomarkers in Underserved Adult Patients with Asthma

Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients (TELE-TOC): A study protocol for a type II hybrid effectiveness-implementation randomised, pragmatic clinical trial of a pharmacist-led intervention.

Citation
Ramadurai D, Lee CT, Traeger L, Pucci G, Jackson-Sagredo A, Shah S, Abraham J, Arora VM, Press VG. Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients (TELE-TOC): A study protocol for a type II hybrid effectiveness-implementation randomised, pragmatic clinical trial of a pharmacist-led intervention. BMJ Open. 2025 Nov 4;15(11):e105521. doi: 10.1136/bmjopen-2025-105521. PMID: 41193196; PMCID: PMC12587980.
Principal Investigator
Press, Valerie G.
Abraham, Joanna
Arora, Vineet
Project Name
TELE-TOC Telehealth Education Leveraging Electronic Transitions of Care for COPD Patients

Implementing and evaluating the clinical outcomes of an asthma management mobile application.

Citation
Sakleshpur S, Mowrey W, Green S, Feldman J, Reznik M, Su Z, Zheng K, Jariwala SP. Implementing and evaluating the clinical outcomes of an asthma management mobile application. Respir Care. 2025 Oct;70(10):1257-1266. doi: 10.1089/respcare.12312. Epub 2025 May 19. PMID: 40379484.
Principal Investigator
Jariwala, Sunit
Project Name
Adapting, Scaling, and Spreading an Algorithmic Asthma Mobile Intervention to Promote Patient-Reported Outcomes Within Primary Care Settings

Shared decision making using digital twins in knee osteoarthritis care: A randomized clinical trial of an AI-enabled decision aid versus education alone on decision quality, physical function, and user experience.

Citation
Jayakumar P, Rathouz PJ, Lin E, Trutner Z, Uhler LM, Andrawis J, Koenig KM, Tsevat J, Bozic KJ. Shared decision making using digital twins in knee osteoarthritis care: A randomized clinical trial of an AI-enabled decision aid versus education alone on decision quality, physical function, and user experience. EClinicalMedicine. 2025 Oct 4;89:103545. doi: 10.1016/j.eclinm.2025.103545. PMID: 41112505; PMCID: PMC12528923.
Principal Investigator
Bozic, Kevin John
Tsevat, Joel
Project Name
Incorporating Patient-Reported Outcomes into Shared Decision Making with Patients with Osteoarthritis of the Knee

Evaluation of a novel electric health record sidecar application to display rheumatoid arthritis clinical outcomes during clinic visits: Results of a stepped-wedge cluster randomized pragmatic trial.

Citation
Schmajuk G, Li J, Nasrallah C, Wilson C, Hamblin A, Hariz C, Young C, Shiboski S, Kersey E, Nakamura M, Ashouri JF, Matloubian M, Gross AJ, Barton J, Berrean B, Prugh J, Yazdany J. Evaluation of a novel electric health record sidecar application to display rheumatoid arthritis clinical outcomes during clinic visits: Results of a stepped-wedge cluster randomized pragmatic trial. Arthritis Care Res (Hoboken). 2025 Dec 18:10.1002/acr.70016. doi: 10.1002/acr.70016. Epub ahead of print. PMID: 41412977; PMCID: PMC12900517.
Principal Investigator
Schmajuk, Gabriela
Project Name
Incorporating PRO Data Into RA Clinical Encounters Using Health-IT (PACT)

Pilot trial of Nutri, a digital intervention for personalized dietary management of diabetes in safety-net primary care.

Citation
Burgermaster M, Rosenthal M, Altillo BS, Flores MR, Nayak E, Larson DN, Custer J, Okunade L, Tierney WM, Andrews S, Daniels G, Rathouz PJ. Pilot trial of Nutri, a digital intervention for personalized dietary management of diabetes in safety-net primary care. J Nutr Educ Behav. 2025 Jul;57(7):614-626. doi: 10.1016/j.jneb.2025.03.015. Epub 2025 May 26. PMID: 40418204.
Principal Investigator
Burgermaster, Marissa
Project Name
Clinical Decision Support for Collaborative Diet Goal Setting in Primary Care

Using smart displays to implement an eHealth system for older adults with multiple chronic conditions: Randomized controlled trial.

Citation
Landucci G, Gustafson DH Sr, Mares ML, Pe-Romashko K, Curtin JJ, Hu Y, Maus A, Thompson K, Saunders S, Brown K, Woodburn J, Mutlu B. Using smart displays to implement an eHealth system for older adults with multiple chronic conditions: Randomized controlled trial. JMIR Aging. 2025 Nov 18;8:e75991. doi: 10.2196/75991. PMID: 40961249; PMCID: PMC12673301.
Principal Investigator
Gustafson, David H.
Mares, Marie-Louise
Project Name
Using Smart Devices to Implement an Evidence-based eHealth System for Older Adults

A multicenter randomized trial to improve family clinical note access and outcomes for hospitalized children: The Bedside Notes study protocol.

Citation
O'Hare C, Gatewood AK, Baird J, Brown R, Coller RJ, Desai A, Egan A, Gerber D, McGuire T, Singh-Verdeflor KD, Smith CA, Verdelis GA, Warner G, Wong S, Kelly MM. A multicenter randomized trial to improve family clinical note access and outcomes for hospitalized children: The Bedside Notes study protocol. J Hosp Med. 2025 Nov;20(11):1256-1264. doi: 10.1002/jhm.70155. Epub 2025 Aug 21. PMID: 40839550; PMCID: PMC12443148.
Principal Investigator
Kelly, Michelle M.
Project Name
Bedside Notes: A Multicenter Trial to Improve Family Clinical Note Access and Outcomes for Hospitalized Children